DRY POWDER FORMULATION OF AZOLE DERIVATIVE FOR INH

专利名称：DRY POWDER FORMULATION OF AZOLE

DERIVATIVE FOR INHALATION

发明人：Arthur DEBOECK,Francis

VANDERBIST,Philippe BAUDIER,ThamiSEBTI,Christophe DURET,Karim AMIGHI

申请号：US15155699申请日：20160516

公开号：US20170087154A1公开日：20170330

摘要：A spray dried-powder composition for inhalation comprising particles (X)containing (a) between 5 and 50% by weight of at least one azole derivative in amorphousstate but not in crystalline structure and (b) at least one matricial agent to thecomposition selected from a group consisting of polyol such as sorbitol, mannitol andxylitol; a monosaccharides such as glucose and arabinose; disaccharide such as lactose,maltose, saccharose and dextrose; cholesterol, and any mixture thereof, wherein thecomposition provides a dissolution rate of said azole derivative of at least, 5% within 10minutes, 10% within 20 minutes and 40% within 60 minutes when tested in the dissolutionapparatus type 2 of the United States Pharmacopoeia at 50 rotation per minute, 37° C. in900 milliliters of an aqueous dissolution medium adjusted at pH 1.2 and containing 0.3%of sodium laurylsulfate.

申请人：Arthur DEBOECK,Francis VANDERBIST,Philippe BAUDIER,ThamiSEBTI,Christophe DURET,Karim AMIGHI

地址：Gurabo PR US,Beersel BE,Uccle BE,Braine-le-Comte BE,Bouillon BE,Woluwe Saint

Pierre BE

国籍：US,BE,BE,BE,BE,BE

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